SERPINH1 Antikörper (AA 247-418) (Fluoro488)

Produktnummer ABIN8036283

Der Kaninchen Polyklonal anti-SERPINH1 Antikörper wird verwendet zum Nachweis von SERPINH1 in Proben von Human, Maus und Ratte. Er wurde validiert für FACS.

Kurzübersicht für SERPINH1 Antikörper (AA 247-418) (Fluoro488) (ABIN8036283)

Target: SERPINH1 (Serpin Family H Member 1 (SERPINH1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SERPINH1 Antikörper ist konjugiert mit Fluoro488

Applikation: Flow Cytometry (FACS)

Produktdetails anti-SERPINH1 Antikörper (Fluoro488)

Bindungsspezifität: AA 247-418

Verwendungszweck: Anti-Hsp47/SERPINH1 Antibody Fluoro488 Conjugated

Spezifität: No cross reactivity with other proteins.

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Homologie: Human Hsp47 shares 97% amino acid (aa) sequence identity with both mouse,rat Hsp47.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human Hsp47 recombinant protein (Position: D247-L418). Human Hsp47 shares 97% amino acid (aa) sequence identity with both mouse and rat Hsp47.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Flow Cytometry, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Haltbarkeit: 12 months

Details zu SERPINH1

Target: SERPINH1 (Serpin Family H Member 1 (SERPINH1))

Andere Bezeichnung: SERPINH1

Hintergrund:

Background: Heat shock protein 47, also known as SERPINH1 or HSP47, is a serpin which serves as a human chaperone protein for collagen. This protein is a member of the serpin superfamily of serine proteinase inhibitors. Its expression is induced by heat shock. The protein localizes to the endoplasmic reticulum lumen and binds collagen, thus it is thought to be a molecular chaperone involved in the maturation of collagen molecules. Autoantibodies to this protein have been found in patients with rheumatoid arthritis. It has been found that HSP47 monitors the integrity of the triple helix of type I procollagen at the ER/cis-Golgi boundary and, when absent, the rate of transit from the ER to the Golgi is increased and the helical structure is compromised.

Gene Full Name: serpin family H member 1

Sequence Similarities: Belongs to the serpin family.

Gen-ID: 871

UniProt: P50454