RGMB Antikörper (AA 47-404) (Cy3)

Produktnummer ABIN8032074

Der Kaninchen Polyklonal anti-RGMB Antikörper wird verwendet zum Nachweis von RGMB in Proben von Human und Maus. Er wurde validiert für FACS.

Kurzübersicht für RGMB Antikörper (AA 47-404) (Cy3) (ABIN8032074)

Target: RGMB (RGM Domain Family, Member B (RGMB))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RGMB Antikörper ist konjugiert mit Cy3

Applikation: Flow Cytometry (FACS)

Produktdetails anti-RGMB Antikörper (Cy3)

Bindungsspezifität: AA 47-404

Verwendungszweck: Anti-DRAGON/RGMB Antibody Cy3 Conjugated

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human DRAGON/RGMB recombinant protein (Position: D47-R404).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Flow Cytometry, 1-3 μg/1x10⁶ cells

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Haltbarkeit: 12 months

Details zu RGMB

Target: RGMB (RGM Domain Family, Member B (RGMB))

Andere Bezeichnung: RGMB

Hintergrund:

Background: Repulsive guidance molecule B (RGMb), also known as DRAGON (DRG11-responsive axonal guidance and outgrowth of neurite), is a bone morphogenetic protein (BMP) co-receptor of the repulsive guidance molecule family. In humans this protein is encoded by the RGMB gene. RGMB is a glycosylphosphatidylinositol (GPI)-anchored member of the repulsive guidance molecule family (see also RGMA and RGMC) and contributes to the patterning of the developing nervous system. There is a potential association between RGMs and cancer bone metastasis, as RGMs coordinate bone morphogenetic protein (BMP) signaling. RGMB may act as a negative regulator in vitro in breast cancer and prostate cancer through BMP signalling. Furthermore, aberrant expression of RGMs was indicated in breast cancer. The perturbed expression was associated with disease progression and poor prognosis.

Gene Full Name: repulsive guidance molecule BMP co-receptor b

Gen-ID: 285704

UniProt: Q6NW40