ALIX Antikörper (AA 2-330) (APC)

Produktnummer ABIN8025636

Der Maus Monoklonal anti-ALIX Antikörper wird verwendet zum Nachweis von ALIX in Proben von Human, Maus und Ratte. Er wurde validiert für FACS.

Kurzübersicht für ALIX Antikörper (AA 2-330) (APC) (ABIN8025636)

Target: ALIX (PDCD6IP) (Programmed Cell Death 6 Interacting Protein (PDCD6IP))

Reaktivität: Human, Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ALIX Antikörper ist konjugiert mit APC

Applikation: Flow Cytometry (FACS)

Klon: 14D10

Produktdetails anti-ALIX Antikörper (APC)

Bindungsspezifität: AA 2-330

Verwendungszweck: Anti-ALIX/PDCD6IP Antibody(monoclonal, 14D10) APC Conjugated

Spezifität: No cross reactivity with other proteins.

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Homologie: Human PDCD6IP shares?96.7%,95.2% amino?acid? (aa)?sequence?identity?with mouse?and rat PDCD6IP,respectively.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human PDCD6IP recombinant protein (Position: A2-D330). Human PDCD6IP shares?96.7% and 95.2% amino?acid? (aa)?sequence?identity?with mouse?and rat PDCD6IP, respectively.

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Flow Cytometry, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Haltbarkeit: 12 months

Details zu ALIX

Target: ALIX (PDCD6IP) (Programmed Cell Death 6 Interacting Protein (PDCD6IP))

Andere Bezeichnung: PDCD6IP

Hintergrund:

Background: Programmed cell death 6-interacting protein is a protein that in humans is encoded by the PDCD6IP gene. This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene Full Name: programmed cell death 6 interacting protein

Gen-ID: 10015

UniProt: Q8WUM4

Pathways: p53 Signalweg, EGFR Signaling Pathway, Sensory Perception of Sound, Cellular Response to Molecule of Bacterial Origin, Tube Formation