PAWR Antikörper (AA 160-255)

Produktnummer ABIN8025296

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch PAWR in WB, ELISA, FACS, IF und ICC. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für PAWR Antikörper (AA 160-255) (ABIN8025296)

Target: PAWR (PRKC, Apoptosis, WT1, Regulator (PAWR))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PAWR Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (IF), Immunocytochemistry (ICC)

Güteklasse: Carrier-free

Produktdetails anti-PAWR Antikörper

Bindungsspezifität: AA 160-255

Verwendungszweck: Anti-PAWR Antibody

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Homologie: Human PAWR shares 82.3%,81.2% amino acid (aa) sequence identity with mouse,rat PAWR,respectively.

Produktmerkmale: Anti-PAWR Antibody. Tested in ELISA, IF, ICC, WB, Flow Cytometry applications. This antibody reacts with Human.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human PAWR recombinant protein (Position: R160-D255). Human PAWR shares 82.3% and 81.2% amino acid (aa) sequence identity with mouse and rat PAWR, respectively.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.1-0.25 μg/mL, Human Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human Flow Cytometry (Fixed), 1-3 μg /1x10⁶ cells, Human ELISA, 0.1-0.5 μg/mL, -

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu PAWR

Target: PAWR (PRKC, Apoptosis, WT1, Regulator (PAWR))

Andere Bezeichnung: PAWR

Hintergrund:

Background: PRKC apoptosis WT1 regulator protein, or Prostate apoptosis response-4, is a tumor-suppressor protein coded for in the human by the PAWR gene, that induces apoptosis in cancer cells, but not in normal cells. This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms. The intracellular mechanism involves the inhibition of pro-survival pathways and the activation of Fas-mediated apoptosis, while the extracellular mechanism involves the binding of a secreted form of this protein to glucose regulated protein 78 (GRP78) on the cell surface, which leads to activation of the extrinsic apoptotic pathway. This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated different tumors. The encoded protein also plays an important role in the progression of age-related diseases.

Gene Full Name: pro-apoptotic WT1 regulator

Molekulargewicht: 41 kDa

Gen-ID: 5074

UniProt: Q96IZ0