Plakophilin 2 Antikörper (AA 369-804) (HRP)

Produktnummer ABIN8022785

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch Plakophilin 2 in WB, ELISA und IHC. Es zeigt Reaktivität gegenüber Proben von Human, Ratte und Maus.

Kurzübersicht für Plakophilin 2 Antikörper (AA 369-804) (HRP) (ABIN8022785)

Target: Plakophilin 2 (PKP2)

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Plakophilin 2 Antikörper ist konjugiert mit HRP

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-Plakophilin 2 Antikörper (HRP)

Bindungsspezifität: AA 369-804

Verwendungszweck: Anti-PKP2 Antibody HRP Conjugated

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Homologie: Human PKP2 shares 82.8%,79.4% amino acid (aa) sequence identity with mouse,rat PKP2,respectively.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human PKP2 recombinant protein (Position: R369-Q804). Human PKP2 shares 82.8% and 79.4% amino acid (aa) sequence identity with mouse and rat PKP2, respectively.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu Plakophilin 2

Target: Plakophilin 2 (PKP2)

Andere Bezeichnung: PKP2

Hintergrund:

Background: Plakophilin-2 is a protein that in humans is encoded by the PKP2 gene. This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This gene may regulate the signaling activity of beta-catenin and is required to maintain transcription of genes that control intracellular calcium cycling including ryanodine receptor 2, ankyrin-B, triadin, and calcium channel, voltage-dependent, L type, alpha 1C. Mutations in this gene are associated with different inherited cardiac conditions including Arrythmogenic Cardiomyopathy, Brugada Syndrome, and Idiopathic Ventricular Fibrillation. A processed pseudogene with high similarity to this gene has been mapped to chromosome 12p13.

Gene Full Name: plakophilin 2

Gen-ID: 5318

UniProt: Q99959

Pathways: Cell-Cell Junction Organization, SARS-CoV-2 Protein Interaktom, Phosphorylierungen bei SARS-CoV-2 Infektion