PLCE1 Antikörper (AA 4-735) (PE)

Produktnummer ABIN8022177

Der Kaninchen Polyklonal anti-PLCE1 Antikörper wird verwendet zum Nachweis von PLCE1 in Proben von Human. Er wurde validiert für FACS.

Kurzübersicht für PLCE1 Antikörper (AA 4-735) (PE) (ABIN8022177)

Target: PLCE1 (Phospholipase C, epsilon 1 (PLCE1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PLCE1 Antikörper ist konjugiert mit PE

Applikation: Flow Cytometry (FACS)

Produktdetails anti-PLCE1 Antikörper (PE)

Bindungsspezifität: AA 4-735

Verwendungszweck: Anti-PLCE1 Antibody PE Conjugated

Homologie: Human PLCE1 shares 74.6%,73.6% amino acid (aa) sequence identity with mouse,rat PLCE1,respectively.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human PLCE1 recombinant protein (Position: E4-E735). Human PLCE1 shares 74.6% and 73.6% amino acid (aa) sequence identity with mouse and rat PLCE1, respectively.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Flow Cytometry, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Haltbarkeit: 12 months

Details zu PLCE1

Target: PLCE1 (Phospholipase C, epsilon 1 (PLCE1))

Andere Bezeichnung: PLCE1

Hintergrund:

Background: Phospholipase C epsilon 1 (PLCE1) is an enzyme that in humans is encoded by the PLCE1 gene. This gene encodes a phospholipase enzyme that catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate to generate two second messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). These second messengers subsequently regulate various processes affecting cell growth, differentiation, and gene expression. This enzyme is regulated by small monomeric GTPases of the Ras and Rho families and by heterotrimeric G proteins. In addition to its phospholipase C catalytic activity, this enzyme has an N-terminal domain with guanine nucleotide exchange (GEF) activity. Mutations in this gene cause early-onset nephrotic syndrome, characterized by proteinuria, edema, and diffuse mesangial sclerosis or focal and segmental glomerulosclerosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene Full Name: phospholipase C epsilon 1

Gen-ID: 51196

UniProt: Q9P212

Pathways: EGFR Signaling Pathway, Regulation of G-Protein Coupled Receptor Protein Signaling