PER2 Antikörper (AA 13-330) (Fluoro550)

Produktnummer ABIN8020497

Der Kaninchen Polyklonal anti-PER2 Antikörper wird verwendet zum Nachweis von PER2 in Proben von Human. Er wurde validiert für FACS.

Kurzübersicht für PER2 Antikörper (AA 13-330) (Fluoro550) (ABIN8020497)

Target: PER2 (Period Circadian Protein 2 (PER2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PER2 Antikörper ist konjugiert mit Fluoro550

Applikation: Flow Cytometry (FACS)

Produktdetails anti-PER2 Antikörper (Fluoro550)

Bindungsspezifität: AA 13-330

Verwendungszweck: Anti-PER2 Antibody Fluoro550 Conjugated

Spezifität: No cross reactivity with other proteins.

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Homologie: Human PER2 shares 84%,83% amino acid (aa) sequence identity with mouse,rat PER2,respectively.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human PER2 recombinant protein (Position: N13-K330). Human PER2 shares 84% and 83% amino acid (aa) sequence identity with mouse and rat PER2, respectively.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Flow Cytometry, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Haltbarkeit: 12 months

Details zu PER2

Target: PER2 (Period Circadian Protein 2 (PER2))

Andere Bezeichnung: PER2

Hintergrund:

Background: The PER2 gene encodes the period circadian protein homolog 2 protein in humans. This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. PER2 is mapped to 2q37.3. It has been showed that PER2 can positively stimulate activity of the Bmal1-Npas2 transcription complex and, in turn, Npas2 transcriptionally regulates delta-aminolevulinate synthase. PER2 is involved in a negative-feedback loop that attenuates estrogen stimulation and links the circadian cycle to estrogen receptor signaling. The rhythmic levels of PER2 are critical for circadian oscillations in cells and intact organisms. What's more, the PER2 gene also functions in tumor suppression by regulating DNA damage-responsive pathways.

Gene Full Name: period circadian regulator 2

Sequence Similarities: Contains 1 PAC (PAS-associated C-terminal) domain.

Gen-ID: 8864

UniProt: O15055