PIN1 Antikörper (AA 1-163) (Cy3)

Produktnummer ABIN8020285

Der Cy3-konjugierte Maus Monoklonal anti-PIN1 Antikörper (Klon 5E5) (ABIN8020285) detektiert spezifisch PIN1 in FACS. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Ratte und Affe.

Kurzübersicht für PIN1 Antikörper (AA 1-163) (Cy3) (ABIN8020285)

Target: PIN1 (Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1))

Reaktivität: Human, Ratte, Affe

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PIN1 Antikörper ist konjugiert mit Cy3

Applikation: Flow Cytometry (FACS)

Klon: 5E5

Produktdetails anti-PIN1 Antikörper (Cy3)

Bindungsspezifität: AA 1-163

Verwendungszweck: Anti-Pin1 Antibody (monoclonal, 5E5) Cy3 Conjugated

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Homologie: Human Pin1 shares 95% amino acid (aa) sequence identity with mouse Pin1.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human Pin1 recombinant protein (Position: M1-E163). Human Pin1 shares 95% amino acid (aa) sequence identity with mouse Pin1.

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Flow Cytometry, 1-3 μg/1x10⁶ cells

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Haltbarkeit: 12 months

Details zu PIN1

Target: PIN1 (Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1))

Andere Bezeichnung: PIN1

Hintergrund:

Background: Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, also called DOD, is an enzyme that in humans is encoded by the PIN1 gene. It is mapped to 19p13.2. The enzyme binds to a subset of proteins and thus plays a role as a post phospho PIN1rol in regulating protein function. Studies have shown that the deregulation of PIN1 may play a pivotal role in various diseases. Notably, the up-regulation of PIN1 may be implicated in certain cancers, and the down-regulation of Pin1 may be implicated in Alzheimer's disease. Inhibitors of PIN1 may have therapeutic implications for cancer and immune disorders. PIN1 activity regulates the outcome of proline-ed kinase (e.g. MAPK, CDK or GSK3) signalling and consequently regulates cell proliferation (in part through control of cyclin D1 levels and stability) and cell survival. PIN1 also has an essential role in maintaining cell proliferation and regulating cyclin D1 function.

Gene Full Name: peptidylprolyl cis/trans isomerase, NIMA-interacting 1

Gen-ID: 5300

UniProt: Q13526