NUB1 Antikörper (AA 190-543) (FITC)

Produktnummer ABIN8014179

Der Kaninchen Polyklonal anti-NUB1 Antikörper wird verwendet zum Nachweis von NUB1 in Proben von Human, Maus, Affe und Ratte. Er wurde validiert für FACS.

Kurzübersicht für NUB1 Antikörper (AA 190-543) (FITC) (ABIN8014179)

Target: NUB1 (Negative Regulator of Ubiquitin-Like Proteins 1 (NUB1))

Reaktivität: Human, Maus, Affe, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NUB1 Antikörper ist konjugiert mit FITC

Applikation: Flow Cytometry (FACS)

Produktdetails anti-NUB1 Antikörper (FITC)

Bindungsspezifität: AA 190-543

Verwendungszweck: Anti-NUB1 Antibody FITC Conjugated

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human NUB1 recombinant protein (Position: K190-D543).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Flow Cytometry, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Haltbarkeit: 12 months

Details zu NUB1

Target: NUB1 (Negative Regulator of Ubiquitin-Like Proteins 1 (NUB1))

Andere Bezeichnung: NUB1

Hintergrund:

Background: NEDD8 µLtimate buster 1 is a protein that in humans is encoded by the NUB1 gene. This gene encodes a protein that functions as a negative regulator of NEDD8, a ubiquitin-like protein that conjugates with cullin family members in order to regulate vital biological events. The protein encoded by this gene regulates the NEDD8 conjugation system post-transcriptionally by recruiting NEDD8 and its conjugates to the proteasome for degradation. This protein interacts with the product of the AIPL1 gene, which is associated with Leber congenital amaurosis, an inherited retinopathy, and mutations in that gene can abolish interaction with this protein, which may contribute to the pathogenesis. This protein is also known to accumulate in Lewy bodies in Parkinson's disease and dementia with Lewy bodies, and in glial cytoplasmic inclusions in multiple system atrophy, with this abnormal accumulation being specific to alpha-synucleinopathy lesions. Alternative splicing of this gene results in multiple transcript variants.

Gene Full Name: negative regulator of ubiquitin like proteins 1

Gen-ID: 51667

UniProt: Q9Y5A7