MGA (C-Term) Antikörper (Fluoro550)

Produktnummer ABIN8009884

Der Fluoro550-konjugierte Kaninchen Polyklonal anti-MGA Antikörper (ABIN8009884) detektiert spezifisch MGA in FACS. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für MGA (C-Term) Antikörper (Fluoro550) (ABIN8009884)

Target: MGA

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Fluoro550

Applikation: Flow Cytometry (FACS)

Produktdetails

Bindungsspezifität: C-Term

Verwendungszweck: Anti-MGA Antibody Fluoro550 Conjugated

Spezifität: No cross reactivity with other proteins.

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Homologie: different from the related mouse sequence by two amino acids.

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human MGA, different from the related mouse sequence by two amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Flow Cytometry, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Haltbarkeit: 12 months

Antigendetails

Target: MGA

Hintergrund:

Background: Mga is a DNA-binding protein that activates the expression of several important virulence genes in Streptococcus pyogenes  (group A Streptococcus, GAS) in response to changing environmental conditions. It had been found that the mouse transcription factor Max interacted with Mga. Coimmunoprecipitation analysis confirmed that Max and Mga interacted in transfected HEK293 cells. EMSA revealed that Mga required Max for binding to the E-box sequence CACGTG. The isolated T-box of Mga bound the brachyury T-box-binding site in the absence of Max. Mga repressed transcription of a reporter driven from a T-box-binding site, but coexpression of Mga with Max caused transcriptional activation from the T-box-binding site. Expression of Mga with Max, but not Mga alone, activated transcription from a reporter containing the E-box site.

Gene Full Name: MAX dimerization protein MGA

Gen-ID: 23269

UniProt: Q8IWI9