MTDH Antikörper (AA 101-270) (Fluoro488)

Produktnummer ABIN8009311

Der Fluoro488-konjugierte Maus Monoklonal anti-MTDH Antikörper (Klon 2E5G3) (ABIN8009311) detektiert spezifisch MTDH in FACS. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für MTDH Antikörper (AA 101-270) (Fluoro488) (ABIN8009311)

Target: MTDH (Metadherin (MTDH))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MTDH Antikörper ist konjugiert mit Fluoro488

Applikation: Flow Cytometry (FACS)

Klon: 2E5G3

Produktdetails anti-MTDH Antikörper (Fluoro488)

Bindungsspezifität: AA 101-270

Verwendungszweck: Anti-LYRIC Antibody (monoclonal, 2E5G3) Fluoro488 Conjugated

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Homologie: Human LYRIC shares 94% amino acid (aa) sequence identity with both mouse,rat LYRIC.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human LYRIC recombinant protein (Position: D101-Q270). Human LYRIC shares 94% amino acid (aa) sequence identity with both mouse and rat LYRIC.

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Flow Cytometry, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Haltbarkeit: 12 months

Details zu MTDH

Target: MTDH (Metadherin (MTDH))

Andere Bezeichnung: MTDH

Hintergrund:

Background: MTDH (Metadherin), also known as protein LYRIC or astrocyte elevated gene-1 protein (AEG-1) is a protein that in humans is encoded by the MTDH gene. AEG-1 is involved in HIF-1alpha mediated angiogenesis. AEG-1 also interacts with SND1 and involved in RNA-induced silencing complex (RISC) and plays very important role in RISC and miRNA functions. AEG-1 induces an oncogene called Late SV40 factor (LSF/TFCP2) which is involved in thymidylate synthase (TS) induction and DNA biosynthesis synthesis. Late SV40 factor (LSF/TFCP2) enhances angiogenesis by transcriptionally up-regulating matrix metalloproteinase-9 (MMP9). AEG-1 acts as an oncogene in melanoma, malignant glioma, breast cancer and hepatocellular carcinoma. It is highly expressed in these cancers and helps in progression and development of these cancers. It is induced by c-Myc oncogene and plays very important role in anchorage independent growth of cancer cells.

Gene Full Name: metadherin

Gen-ID: 92140

UniProt: Q86UE4

Pathways: Cellular Response to Molecule of Bacterial Origin, Cell-Cell Junction Organization