Meprin B Antikörper (AA 73-489) (HRP)

Produktnummer ABIN8009150

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch Meprin B in WB, IHC und ELISA. Es zeigt Reaktivität gegenüber Proben von Ratte, Human und Maus.

Kurzübersicht für Meprin B Antikörper (AA 73-489) (HRP) (ABIN8009150)

Target: Meprin B (MEP1B) (Meprin A, beta (MEP1B))

Reaktivität: Ratte, Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Meprin B Antikörper ist konjugiert mit HRP

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Produktdetails anti-Meprin B Antikörper (HRP)

Bindungsspezifität: AA 73-489

Verwendungszweck: Anti-MEP1B Antibody HRP Conjugated

Homologie: Human MEP1B shares 82.3%,81.5% amino acid (aa) sequence identity with mouse,rat MEP1B,respectively.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human MEP1B recombinant protein (Position: H73-Q489). Human MEP1B shares 82.3% and 81.5% amino acid (aa) sequence identity with mouse and rat MEP1B, respectively.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu Meprin B

Target: Meprin B (MEP1B) (Meprin A, beta (MEP1B))

Andere Bezeichnung: MEP1B

Hintergrund:

Background: Meprin A subunit beta is a protein that in humans is encoded by the MEP1B gene. Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes, and in leukocytes and certain cancer cells. They are involved in the hydrolysis of a variety of peptide and protein substrates, and have been implicated in cancer and intestinal inflammation. Mature meprins are oligomers of evolutionarily related, but separately encoded alpha and/or beta subunits. Homooligomers of alpha subunit are secreted, whereas, oligomers containing the beta subunit are plasma membrane-bound. This gene encodes the beta subunit. Targeted disruption of this gene in mice affects embryonic viability, renal gene expression profiles, and distribution of the membrane-associated alpha subunit in kidney and intestine.

Gene Full Name: meprin A subunit beta

Gen-ID: 4225

UniProt: Q16820