MECOM Antikörper (AA 125-743) (Biotin)

Produktnummer ABIN8008506

Der Kaninchen Polyklonal anti-MECOM Antikörper wird verwendet zum Nachweis von MECOM in Proben von Human. Er wurde validiert für WB, ELISA und IHC.

Kurzübersicht für MECOM Antikörper (AA 125-743) (Biotin) (ABIN8008506)

Target: MECOM (MDS1 and EVI1 Complex Locus (MECOM))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MECOM Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-MECOM Antikörper (Biotin)

Bindungsspezifität: AA 125-743

Verwendungszweck: Anti-EVI1/MECOM Antibody Biotin Conjugated

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human EVI1/MECOM recombinant protein (Position: E125-D743).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu MECOM

Target: MECOM (MDS1 and EVI1 Complex Locus (MECOM))

Andere Bezeichnung: MECOM

Hintergrund:

Background: MDS1 and EVI1 complex locus protein EVI1 (MECOM) also known as ecotropic virus integration site 1 protein homolog (EVI-1) or positive regulatory domain zinc finger protein 3 (PRDM3) is a protein that in humans is encoded by the MECOM gene. The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene.

Gene Full Name: MDS1 and EVI1 complex locus

Gen-ID: 2122

UniProt: Q03112