CYBB Antikörper (AA 501-570)

Produktnummer ABIN750688

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch CYBB in WB, ELISA, FACS, IHC (p), IF (cc), IF (p) und IHC (fro). Er zeigt eine Reaktivität gegenüber Human, Maus, Ratte, Kaninchen und Huhn und wurde in 6+ Publikationen erwähnt.

Kurzübersicht für CYBB Antikörper (AA 501-570) (ABIN750688)

Target: CYBB (Cytochrome B-245, beta Polypeptide (CYBB))

Reaktivität: Human, Maus, Ratte, Kaninchen, Huhn

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CYBB Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-CYBB Antikörper

Bindungsspezifität: AA 501-570

Kreuzreaktivität: Huhn, Human, Maus, Kaninchen, Ratte

Homologie: Dog,Cow,Pig,Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human NOX2/gp91phox

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-CYBB Antikörper (ABIN750688)

Ye, Wu, Liu, Chen, Zhang, Lu, Zhou, Li, Zhang, Xia, Zhuang, Hang et al.: "Inhibition of leukotriene B4 synthesis protects against early brain injury possibly via reducing the neutrophil-generated inflammatory response and oxidative stress after subarachnoid hemorrhage in ..." in: Behavioural brain research, Vol. 339, pp. 19-27, (2017) (PubMed).

Wakatsuki, Furuno, Ohshima, Araki: "Oxidative stress-dependent phosphorylation activates ZNRF1 to induce neuronal/axonal degeneration." in: The Journal of cell biology, Vol. 211, Issue 4, pp. 881-96, (2015) (PubMed).

Kashiwabara, Ambe, Nakagawa, Watanabe: "Immunohistochemical localization of Nox in mouse circumvallate papillae." in: Tissue & cell, Vol. 47, Issue 6, pp. 550-8, (2015) (PubMed).

Wang, Li, Cheng, Zhang, Narsinh, Li, Li, Qin, Zhang, Li, Su, Chen, Cao: "Activation of Liver X Receptor Improves Viability of Adipose-Derived Mesenchymal Stem Cells to Attenuate Myocardial Ischemia Injury Through TLR4/NF-?B and Keap-1/Nrf-2 Signaling Pathways." in: Antioxidants & redox signaling, (2014) (PubMed).

Dalaklioglu, Tasatargil, Kale, Tanriover, Dilmac, Erin: "Metastatic breast carcinoma induces vascular endothelial dysfunction in Balb-c mice: Role of the tumor necrosis factor-? and NADPH oxidase." in: Vascular pharmacology, Vol. 59, Issue 3-4, pp. 103-11, (2013) (PubMed).

Lagadinou, Sach, Callahan, Rossi, Neering, Minhajuddin, Ashton, Pei, Grose, ODwyer, Liesveld, Brookes, Becker, Jordan: "BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells." in: Cell stem cell, Vol. 12, Issue 3, pp. 329-41, (2013) (PubMed).

Details zu CYBB

Target: CYBB (Cytochrome B-245, beta Polypeptide (CYBB))

Andere Bezeichnung: NOX2/gp91phox

Hintergrund:

Synonyms: CGD, NOX2, IMD34, AMCBX2, GP91-1, GP91PHOX, p91-PHOX, GP91-PHOX, Cytochrome b-245 heavy chain, CGD91-phox, Cytochrome b(558) subunit beta, Cytochrome b558 subunit beta, Heme-binding membrane glycoprotein gp91phox, NADPH oxidase 2, Neutrophil cytochrome b 91 kDa polypeptide, Superoxide-generating NADPH oxidase heavy chain subunit, p22 phagocyte B-cytochrome, CYBB

Background: Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc.

Gen-ID: 1536

UniProt: P04839