HDC Antikörper (AA 12-662) (Cy3)

Produktnummer ABIN7997652

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch HDC in FACS. Es zeigt Reaktivität gegenüber Proben von Human und Maus.

Kurzübersicht für HDC Antikörper (AA 12-662) (Cy3) (ABIN7997652)

Target: HDC (Histidine Decarboxylase (HDC))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HDC Antikörper ist konjugiert mit Cy3

Applikation: Flow Cytometry (FACS)

Produktdetails anti-HDC Antikörper (Cy3)

Bindungsspezifität: AA 12-662

Verwendungszweck: Anti-Histidine decarboxylase/HDC Antibody Cy3 Conjugated

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human Histidine decarboxylase/HDC recombinant protein (Position: R12-V662).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Flow Cytometry, 1-3 μg/1x10⁶ cells

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Haltbarkeit: 12 months

Details zu HDC

Target: HDC (Histidine Decarboxylase (HDC))

Andere Bezeichnung: HDC

Hintergrund:

Background: HDC(Histidine decarboxylase) is the enzyme that catalyzes the reaction that produces histamine from histidine with the help of vitamin B6. The HDC gene is mapped on 15q21.2. The deduced 662-amino acid protein has a molecular mass of 74,148 Da. The gene contains 12 exons spanning approximately 24 kb. The biogenic amine histamine is an important modulator of numerous physiologic processes, including neurotransmission, gastric acid secretion, and smooth muscle tone. The biosynthesis of histamine from histidine is catalyzed by the enzyme L-histidine decarboxylase. This homodimeric enzyme is a pyridoxal phosphate(PLP)-dependent decarboxylase and is highly specific for its histidine substrate. Ercan-Sencicek et al. noted that animal studies had shown that lack of Hdc in mice results in increased locomotor and stereotypic behaviors, as well as increased anxiety.

Gene Full Name: histidine decarboxylase

Gen-ID: 3067

UniProt: P19113