HPSE Antikörper (Middle Region) (HRP)

Produktnummer ABIN7997018

Der HRP-konjugierte Kaninchen Polyklonal anti-HPSE Antikörper (ABIN7997018) detektiert spezifisch HPSE in WB, IHC und ELISA. Dieser Antikörper reagiert spezifisch mit Proben aus Human und Ratte.

Kurzübersicht für HPSE Antikörper (Middle Region) (HRP) (ABIN7997018)

Target: HPSE (Heparanase (HPSE))

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HPSE Antikörper ist konjugiert mit HRP

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Produktdetails anti-HPSE Antikörper (HRP)

Bindungsspezifität: Middle Region

Verwendungszweck: Anti-Heparanase 1/HPSE Antibody HRP Conjugated

Spezifität: No cross reactivity with other proteins.

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Homologie: different from the related mouse,rat sequences by eight amino acids.

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human Heparanase 1, different from the related mouse and rat sequences by eight amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu HPSE

Target: HPSE (Heparanase (HPSE))

Andere Bezeichnung: HPSE

Hintergrund:

Background: Heparanase, also known as HPSE, is an enzyme that acts both at the cell-surface and within the extracellular matrix to degrade polymeric heparan sulfate molecules into shorter chain length oligosaccharides. Heparanase is an endo-beta-D-glucuronidase capable of cleaving heparan sulfate and has been implicated in inflammation and tumor angiogenesis and metastasis. The successful penetration of the endothelial cell layer that lines the interior surface of blood vessels is an important process in the formation of blood borne tumour metastases. Heparan sulfate proteoglycans are major constituents of this layer and it has been shown that increased metastatic potential corresponds with increased heparanase activity for a number of cell lines.

Gene Full Name: heparanase

Sequence Similarities: Belongs to the cyclin family. Cyclin AB subfamily.

Gen-ID: 10855

UniProt: Q9Y251

Pathways: Glycosaminoglycan Metabolic Process