HFE Antikörper (AA 112-227) (HRP)

Produktnummer ABIN7996875

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch HFE in WB, ELISA und IHC. Es zeigt Reaktivität gegenüber Proben von Maus und Ratte.

Kurzübersicht für HFE Antikörper (AA 112-227) (HRP) (ABIN7996875)

Target: HFE (Hemochromatosis (HFE))

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HFE Antikörper ist konjugiert mit HRP

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-HFE Antikörper (HRP)

Bindungsspezifität: AA 112-227

Verwendungszweck: Anti-Hfe Antibody HRP Conjugated

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived mouse Hfe recombinant protein (Position: N112-H227).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu HFE

Target: HFE (Hemochromatosis (HFE))

Andere Bezeichnung: Hfe

Hintergrund:

Background: Human homeostatic iron regulator protein, also known as the HFE protein (High FE2+), is a protein which in humans is encoded by the HFE gene. Enables transferrin receptor binding activity. Involved in positive regulation of gene expression. Acts upstream of or within hormone biosynthetic process and multicellular organismal iron ion homeostasis. Part of HFE-transferrin receptor complex. Is expressed in brain, choroid invagination, diencephalon roof plate, medulla oblongata part of 4th ventricle choroid plexus, and metencephalon part of 4th ventricle choroid plexus. Used to study hemochromatosis type 1. Human ortholog(s) of this gene implicated in several diseases, including acute porphyria (multiple), arthritis (multiple), bone marrow cancer (multiple), hemochromatosis (multiple), and liver disease (multiple). Orthologous to human HFE (homeostatic iron regulator).

Gene Full Name: homeostatic iron regulator

Gen-ID: 15216

UniProt: P70387

Pathways: Transition Metal Ion Homeostasis, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process