FHIT Antikörper (AA 1-147) (PE)

Produktnummer ABIN7991730

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch FHIT in FACS. Es zeigt Reaktivität gegenüber Proben von Human und Ratte.

Kurzübersicht für FHIT Antikörper (AA 1-147) (PE) (ABIN7991730)

Target: FHIT (Fragile Histidine Triad (FHIT))

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FHIT Antikörper ist konjugiert mit PE

Applikation: Flow Cytometry (FACS)

Produktdetails anti-FHIT Antikörper (PE)

Bindungsspezifität: AA 1-147

Verwendungszweck: Anti-FHIT Antibody PE Conjugated

Spezifität: No cross reactivity with other proteins.

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Homologie: Human FHIT shares 90%,87% amino acid (aa) sequences identity with mouse,rat FHIT,respectively.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human FHIT recombinant protein (Position: M1-Q147). Human FHIT shares 90% and 87% amino acid (aa) sequences identity with mouse and rat FHIT, respectively.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Flow Cytometry, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Haltbarkeit: 12 months

Details zu FHIT

Target: FHIT (Fragile Histidine Triad (FHIT))

Andere Bezeichnung: FHIT

Hintergrund:

Background: Bis (5'-adenosyl)-triphosphatase, also known as fragile histidine triad protein (FHIT) is an enzyme that in humans is encoded by the FHIT gene. This gene, a member of the histidine triad gene family, encodes a diadenosine P1,P3-bis (5'-adenosyl)-triphosphate adenylohydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3p14.2, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. Furthermore, FHIT has been shown to synergize with VHL, another tumor suppressor, in protecting against chemically - induced lung cancer. It also acts as a tumor suppressor of HER2/neu driven breast cancer.

Gene Full Name: fragile histidine triad diadenosine triphosphatase

Sequence Similarities: Contains 1 HIT domain.

Gen-ID: 2272

UniProt: P49789