FER Antikörper (AA 1-804)

Produktnummer ABIN7990234

Der Kaninchen Polyklonal anti-FER Antikörper wird verwendet zum Nachweis von FER in Proben von Human, Maus und Ratte. Er wurde validiert für WB und ELISA.

Kurzübersicht für FER Antikörper (AA 1-804) (ABIN7990234)

Target: FER (FER Tyrosine Kinase (FER))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FER Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Güteklasse: Carrier-free

Produktdetails anti-FER Antikörper

Bindungsspezifität: AA 1-804

Verwendungszweck: Anti-FER Antibody

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-FER Antibody. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human FER recombinant protein (Position: M1-R804).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat ELISA, 0.1-0.5 μg/mL, -

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu FER

Target: FER (FER Tyrosine Kinase (FER))

Andere Bezeichnung: FER

Hintergrund:

Background: FER(FPS/FES-Related tyrosine kinase) also known as TYK3, is an enzyme that in humans is encoded by the FER gene. Fer protein is a member of the FPS/FES family of nontransmembrane receptor tyrosine kinases. By in situ hybridization, Morris et al.(1990) concluded that the FER gene is located at 5q21-q22. Treatment of cells with JMP resulted in the release of FER from the cadherin complex and its accumulation in the integrin complex. The accumulation of FER in the integrin complex and the inhibitory effects of JMP could be reversed with a peptide that mimics the first coiled-coil domain of FER. The results suggested that FER mediates crosstalk between CDH2 and ITGB1. In Fer mutant mice, leukocyte emigration was exaggerated in response to LPS without altering vascular permeability, suggesting that FER has a role in regulating innate immunity.

Gene Full Name: FER tyrosine kinase

Molekulargewicht: 95 kDa

Gen-ID: 2241

UniProt: P16591