Keratin 10 Antikörper (AA 151-250)

Produktnummer ABIN749333

Produktdetails anti-Keratin 10 Antikörper

Target: Keratin 10 (KRT10)

Bindungsspezifität: AA 151-250

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Keratin 10 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Spezifität: This antibody my have secondary cross-reactivities with Keratin 12, 13, 14, 15, 17 based on an 85 % sequence similarity in the immunogen range.

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Dog,Cow,Pig,Horse,Rabbit,Guinea Pig

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CK10

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu Keratin 10

Target: Keratin 10 (KRT10)

Andere Bezeichnung: Cytokeratin 10 (KRT10 Produkte)

Synonyme: BCIE antikoerper, BIE antikoerper, CK10 antikoerper, EHK antikoerper, K10 antikoerper, KPP antikoerper, D130054E02Rik antikoerper, K1C1 antikoerper, Krt-1.10 antikoerper, Krt1-10 antikoerper, Ka10 antikoerper, Ker10 antikoerper, KRT10 antikoerper, KRT25 antikoerper, KRT27 antikoerper, KRT28 antikoerper, keratin 10 antikoerper, keratin 10, type I S homeolog antikoerper, keratin, type I cytoskeletal 25 antikoerper, KRT10 antikoerper, Krt10 antikoerper, krt10.S antikoerper, LOC101085587 antikoerper

Hintergrund:

Synonyms: BIE, EHK, K10, KPP, BCIE, CK10, Keratin, type I cytoskeletal 10, Cytokeratin-10, CK-10, Keratin-10, KRT10

Background: Cytokeratin 10 is a heterotetramer of two type I and two type II keratins. Cytokeratin 10 is generally associated with keratin 1. It is seen in all suprabasal cell layers including stratum corneum. A number of alleles are known that mainly differ in the Gly-rich region (positions 490-560). Defects in cytokeratin 10 are a cause of epidermolytic hyperkeratosis (EHK), also known as bullous congenital ichthyosiform erythroderma (BCIE) or bullous erythroderma ichthyosiformis congenita of Brocq. EHK is an hereditary skin disorder characterized by blistering and a marked thickening of the stratum corneum. At birth, affected individuals usually present with redness, blisters and superficial erosions due to cytolysis. Within a few weeks, the erythroderma and blister formation diminish and hyperkeratoses develop. Transmission is autosomal dominant, but most cases are sporadic. Defects in cytokeratin 10 are also a cause of annular epidermolytic ichthyosis (AEI), also known as cyclic ichthyosis with epidermolytic hyperkeratosis. AEI resembles clinical and histologic features of both epidermolytic hyperkeratosis and ichthyosis bullosa of Siemens.

Gen-ID: 3858

UniProt: P13645