FBXW7 Antikörper (AA 151-591) (PE)

Produktnummer ABIN7989450

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch FBXW7 in FACS. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für FBXW7 Antikörper (AA 151-591) (PE) (ABIN7989450)

Target: FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FBXW7 Antikörper ist konjugiert mit PE

Applikation: Flow Cytometry (FACS)

Produktdetails anti-FBXW7 Antikörper (PE)

Bindungsspezifität: AA 151-591

Verwendungszweck: Anti-FBXW7 Antibody PE Conjugated

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Homologie: Human FBXW7 shares 99.3%,98.9% amino acid (aa) sequence identity with mouse,rat FBXW7,respectively.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human FBXW7 recombinant protein (Position: D151-D591). Human FBXW7 shares 99.3% and 98.9% amino acid (aa) sequence identity with mouse and rat FBXW7, respectively.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Flow Cytometry, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Haltbarkeit: 12 months

Details zu FBXW7

Target: FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))

Andere Bezeichnung: FBXW7

Hintergrund:

Background: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class, in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene Full Name: F-box and WD repeat domain containing 7

Gen-ID: 55294

UniProt: Q969H0

Pathways: Notch Signalweg, EGFR Signaling Pathway