DIS3 Antikörper (AA 43-878)

Produktnummer ABIN7989330

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch DIS3 in WB, ELISA, IHC, FACS, IF und ICC. Es zeigt Reaktivität gegenüber Proben von Human, Ratte und Maus.

Kurzübersicht für DIS3 Antikörper (AA 43-878) (ABIN7989330)

Target: DIS3 (Exosome Complex Exonuclease RRP44 (DIS3))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DIS3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF), Immunocytochemistry (ICC)

Güteklasse: Carrier-free

Produktdetails anti-DIS3 Antikörper

Bindungsspezifität: AA 43-878

Verwendungszweck: Anti-DIS3 Antibody

Homologie: Human DIS3 shares 92.8% amino acid (aa) sequence identity with mouse DIS3.

Produktmerkmale: Anti-DIS3 Antibody. Tested in WB, IHC, ICC/IF, Flow Cytometry, ELISA applications. This antibody reacts with Human, Mouse, Rat.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human DIS3 recombinant protein (Position: H43-K878). Human DIS3 shares 92.8% amino acid (aa) sequence identity with mouse DIS3.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.25-0.5 μg/mL, Human Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Human, Mouse, Rat Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human ELISA, 0.1-0.5 μg/mL, -

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu DIS3

Target: DIS3 (Exosome Complex Exonuclease RRP44 (DIS3))

Andere Bezeichnung: DIS3

Hintergrund:

Background: Exosome complex exonuclease RRP44 or Dis3 is an enzyme that in humans is encoded by the DIS3 gene. The DIS3 gene encodes a catalytic subunit of the exosome complex, an essential RNA degradation machinery involved in multiple aspects of RNA metabolism, including RNA processing, quality control, and turnover. DIS3 functions as an exonuclease, playing a key role in degrading various RNA species, such as messenger RNA (mRNA), ribosomal RNA (rRNA), and transfer RNA (tRNA). Its activity is crucial for maintaining cellular RNA homeostasis and gene expression regulation. Dysregulation of DIS3 expression or activity has been linked to various human diseases, including cancer and neurodegenerative disorders. Understanding the molecular mechanisms underlying DIS3 function is essential for elucidating its role in RNA metabolism and its potential implications for disease pathology and therapeutic targeting.

Gene Full Name: DIS3 exosome endoribonuclease and 3'-5' exoribonuclease

Molekulargewicht: 109 kDa

Gen-ID: 22894

UniProt: Q9Y2L1