EIF4B Antikörper (AA 1-611) (Fluoro594)

Produktnummer ABIN7989037

Der Kaninchen Polyklonal anti-EIF4B Antikörper wird verwendet zum Nachweis von EIF4B in Proben von Human, Maus und Ratte. Er wurde validiert für FACS.

Kurzübersicht für EIF4B Antikörper (AA 1-611) (Fluoro594) (ABIN7989037)

Target: EIF4B (Eukaryotic Translation Initiation Factor 4B (EIF4B))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EIF4B Antikörper ist konjugiert mit Fluoro594

Applikation: Flow Cytometry (FACS)

Produktdetails anti-EIF4B Antikörper (Fluoro594)

Bindungsspezifität: AA 1-611

Verwendungszweck: Anti-EIF4B Antibody Fluoro594 Conjugated

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human EIF4B recombinant protein (Position: M1-E611).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Flow Cytometry, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Haltbarkeit: 12 months

Details zu EIF4B

Target: EIF4B (Eukaryotic Translation Initiation Factor 4B (EIF4B))

Andere Bezeichnung: EIF4B

Hintergrund:

Background: Eukaryotic translation initiation factor 4B is a protein that in humans is encoded by the EIF4B gene. Eukaryotic initiation factor 4B (eIF4B) is thought to assist the eIF4F complex in translation initiation. In plants, eIF4B is known to interact with the poly-(A) binding protein, increasing its poly-(A) binding activity. Heat shock and serum starvation cause dephosphorylation of eIF4B at multiple sites with kinetics similar to those of the corresponding inhibition of translation, while phosphorylation of eIF4B following insulin treatment correlates well with an observed increase in translation. Multiple kinases, including p70 S6 kinase, can phosphorylate eIF4B in vitro, and at least one serum-inducible eIF4B phosphorylation site is sensitive to rapamycin and LY294002. Recently, Ser406 was identified as a novel phosphorylation site regulated by mitogens, and the phosphorylation of this site is dependent on MEK and mTOR activity. This phosphorylation is shown to be essential for the translational activity of eIF4B.

Gene Full Name: eukaryotic translation initiation factor 4B

Gen-ID: 1975

UniProt: P23588