EFS Antikörper (AA 183-553) (Fluoro488)

Produktnummer ABIN7987423

Der Kaninchen Polyklonal anti-EFS Antikörper wird verwendet zum Nachweis von EFS in Proben von Human, Maus und Ratte. Er wurde validiert für FACS.

Kurzübersicht für EFS Antikörper (AA 183-553) (Fluoro488) (ABIN7987423)

Target: EFS (Embryonal Fyn-Associated Substrate (EFS))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EFS Antikörper ist konjugiert mit Fluoro488

Applikation: Flow Cytometry (FACS)

Produktdetails anti-EFS Antikörper (Fluoro488)

Bindungsspezifität: AA 183-553

Verwendungszweck: Anti-EFS Antibody Fluoro488 Conjugated

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Homologie: Human EFS shares 82.2% amino acid (aa) sequence identity with mouse EFS.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human EFS recombinant protein (Position: E183-T553). Human EFS shares 82.2% amino acid (aa) sequence identity with mouse EFS.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Flow Cytometry, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Haltbarkeit: 12 months

Details zu EFS

Target: EFS (Embryonal Fyn-Associated Substrate (EFS))

Andere Bezeichnung: EFS

Hintergrund:

Background: The protein encoded by this gene is a member of the CAS (CRK-associated substrate) family of adaptor proteins which typically serve as scaffolds for the assembly of larger signaling complexes. These complexes form at the cell surface where integrin binding leads to the subsequent phosphorylation of a CAS protein. Additional binding of SRC family kinases leads to CAS hyperphosphorylation and the creation of binding sites for CRK and other proteins that cause actin cytoskeleton reorganization. This gene plays a role in integrin-mediated cell attachment, spreading, and migration and also plays a role in both normal and malignant cellular transformation. This broadly expressed gene has been shown to play a role in neurite outgrowth and its expression in the thymus and lymphocytes is important for T cell maturation and the development of immunological self-tolerance. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.

Gene Full Name: embryonal Fyn-associated substrate

Gen-ID: 10278

UniProt: O43281