ECD/SGT1 Antikörper (AA 50-567) (APC)

Produktnummer ABIN7987096

Der Kaninchen Polyklonal anti-ECD/SGT1 Antikörper wird verwendet zum Nachweis von ECD/SGT1 in Proben von Human. Er wurde validiert für FACS.

Kurzübersicht für ECD/SGT1 Antikörper (AA 50-567) (APC) (ABIN7987096)

Target: ECD/SGT1 (ECD) (Ecdysoneless Homolog (ECD))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ECD/SGT1 Antikörper ist konjugiert mit APC

Applikation: Flow Cytometry (FACS)

Produktdetails anti-ECD/SGT1 Antikörper (APC)

Bindungsspezifität: AA 50-567

Verwendungszweck: Anti-SGT1/ECD Antibody APC Conjugated

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human SGT1/ECD recombinant protein (Position: L50-Q567).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Flow Cytometry, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Haltbarkeit: 12 months

Details zu ECD/SGT1

Target: ECD/SGT1 (ECD) (Ecdysoneless Homolog (ECD))

Andere Bezeichnung: ECD

Hintergrund:

Background: Protein SGT1 is a protein that in humans is encoded by the ECD gene. Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP. May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes. Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins. The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex. May play a role in regulation of pre-mRNA splicing.

Gene Full Name: ecdysoneless cell cycle regulator

Gen-ID: 11319

UniProt: O95905

Pathways: Regulation of Carbohydrate Metabolic Process