DCLK1 Antikörper (AA 1-728) (APC)

Produktnummer ABIN7986303

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch DCLK1 in FACS. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für DCLK1 Antikörper (AA 1-728) (APC) (ABIN7986303)

Target: DCLK1 (Doublecortin-Like Kinase 1 (DCLK1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DCLK1 Antikörper ist konjugiert mit APC

Applikation: Flow Cytometry (FACS)

Produktdetails anti-DCLK1 Antikörper (APC)

Bindungsspezifität: AA 1-728

Verwendungszweck: Anti-DCLK1 Antibody APC Conjugated

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Homologie: Human DCLK1 shares 96.4% amino acid (aa) sequence identity with mouse DCLK1.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human DCLK1 recombinant protein (Position: M1-S728). Human DCLK1 shares 96.4% amino acid (aa) sequence identity with mouse DCLK1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Flow Cytometry, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Haltbarkeit: 12 months

Details zu DCLK1

Target: DCLK1 (Doublecortin-Like Kinase 1 (DCLK1))

Andere Bezeichnung: DCLK1

Hintergrund:

Background: This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.

Gene Full Name: doublecortin like kinase 1

Gen-ID: 9201

UniProt: O15075