C4orf49 Antikörper (AA 1-155) (Biotin)

Produktnummer ABIN7980103

Der Kaninchen Polyklonal anti-C4orf49 Antikörper wird verwendet zum Nachweis von C4orf49 in Proben von Human, Maus und Ratte. Er wurde validiert für WB, ELISA und IHC.

Kurzübersicht für C4orf49 Antikörper (AA 1-155) (Biotin) (ABIN7980103)

Target: C4orf49 (Chromosome 4 Open Reading Frame 49 (C4orf49))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser C4orf49 Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-C4orf49 Antikörper (Biotin)

Bindungsspezifität: AA 1-155

Verwendungszweck: Anti-MGARP Antibody Biotin Conjugated

Homologie: Human C4orf49,MGARP shares 67.3% amino acid (aa) sequence identity with mouse C4orf49,MGARP.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human C4orf49/MGARP recombinant protein (Position: M1-E155). Human C4orf49/MGARP shares 67.3% amino acid (aa) sequence identity with mouse C4orf49/MGARP.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu C4orf49

Target: C4orf49 (Chromosome 4 Open Reading Frame 49 (C4orf49))

Andere Bezeichnung: MGARP

Hintergrund:

Background: MGARP is highly enriched in steroidogenic tissues and the visual system. Interestingly, its expression increases as mice develop. Early in development, MGARP is mainly detected in the retina and adrenal gland. At this early developmental stage, its expression is not detectable in the gonads, but its expression in the gonads dramatically increases during the first 2-4 wk after birth. Importantly, MGARP levels correlate with estrogen levels in the ovaries during the estrous cycle, and estrogen regulates the expression of MGARP in a tissue-specific manner and through a feedback regulatory mechanism. Functional inhibition of GnRH with an antagonist strongly reduces MGARP levels, and knockout of leptin (ob/ob) significantly reduces the MGARP expression in follicular granular cells. We proposed a model that elucidates the role MGARP plays in the HPG axis. Within the HPG axis loop, MGARP participates in hormone biosynthesis while being under the regulation of the hormones derived from the HPG axis.

Gene Full Name: mitochondria localized glutamic acid rich protein

Gen-ID: 84709

UniProt: Q8TDB4