CLCN3 Antikörper (AA 293-752) (APC)

Produktnummer ABIN7979538

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch CLCN3 in FACS. Es zeigt Reaktivität gegenüber Proben von Ratte und Human.

Kurzübersicht für CLCN3 Antikörper (AA 293-752) (APC) (ABIN7979538)

Target: CLCN3 (Chloride Channel 3 (CLCN3))

Reaktivität: Ratte, Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CLCN3 Antikörper ist konjugiert mit APC

Applikation: Flow Cytometry (FACS)

Produktdetails anti-CLCN3 Antikörper (APC)

Bindungsspezifität: AA 293-752

Verwendungszweck: Anti-CLCN3 Antibody APC Conjugated

Homologie: Human CLCN3 shares 99.6% amino acid (aa) sequence identity with mouse CLCN3.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human CLCN3 recombinant protein (Position: G293-R752). Human CLCN3 shares 99.6% amino acid (aa) sequence identity with mouse CLCN3.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Flow Cytometry, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Haltbarkeit: 12 months

Details zu CLCN3

Target: CLCN3 (Chloride Channel 3 (CLCN3))

Andere Bezeichnung: CLCN3

Hintergrund:

Background: H+/Cl? exchange transporter 3 is a protein that in humans is encoded by the CLCN3 gene. This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Gene Full Name: chloride voltage-gated channel 3

Gen-ID: 1182

UniProt: P51790