CD1a Antikörper (Middle Region) (HRP)

Produktnummer ABIN7976356

Der Kaninchen Polyklonal anti-CD1a Antikörper wird verwendet zum Nachweis von CD1a in Proben von Human. Er wurde validiert für IHC, WB und ELISA.

Kurzübersicht für CD1a Antikörper (Middle Region) (HRP) (ABIN7976356)

Target: CD1a

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CD1a Antikörper ist konjugiert mit HRP

Applikation: Immunohistochemistry (IHC), Western Blotting (WB), ELISA

Produktdetails anti-CD1a Antikörper (HRP)

Bindungsspezifität: Middle Region

Verwendungszweck: Anti-CD1a Antibody HRP Conjugated

Spezifität: No cross reactivity with other proteins.

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human CD1a.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu CD1a

Target: CD1a

Andere Bezeichnung: CD1A

Hintergrund:

Background: CD1A (Thymocyte antigen CD1A) also known as CD1, is a human protein encoded by the CD1A gene. CD1A is 1 of 5 distinct CD1 genes that are variably conserved in different mammalian species. This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin.The CD1A gene is mapped on 1q23.1. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. CD1A is concentrated in the early or recycling endosome. Moody et al. (2004) reported that CD1A presents to T cells a family of previously unknown lipopeptides from Mycobacterium tuberculosis, named didehydroxymycobactins because of their structural relation to mycobactin siderophores. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Apolipoprotein E (107741) binds lipid antigens and delivers them by receptor-mediated uptake into endosomal compartments containing CD1 in antigen-presenting cells.

Gene Full Name: CD1a molecule

Sequence Similarities: Contains 9 SRCR domains.

Gen-ID: 909

UniProt: P06126

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process