Aconitase 1 Antikörper (AA 1-137) (APC)

Produktnummer ABIN7965590

Der Kaninchen Polyklonal anti-Aconitase 1 Antikörper wird verwendet zum Nachweis von Aconitase 1 in Proben von Human, Maus, Ratte und Affe. Er wurde validiert für FACS.

Kurzübersicht für Aconitase 1 Antikörper (AA 1-137) (APC) (ABIN7965590)

Target: Aconitase 1 (ACO1)

Reaktivität: Human, Maus, Ratte, Affe

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Aconitase 1 Antikörper ist konjugiert mit APC

Applikation: Flow Cytometry (FACS)

Produktdetails anti-Aconitase 1 Antikörper (APC)

Bindungsspezifität: AA 1-137

Verwendungszweck: Anti-Aconitase 1/ACO1 Antibody APC Conjugated

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human Aconitase 1/ACO1 recombinant protein (Position: M1-D137).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Flow Cytometry, Optimal dilutions should be determined by end users.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Haltbarkeit: 12 months

Details zu Aconitase 1

Target: Aconitase 1 (ACO1)

Andere Bezeichnung: ACO1

Hintergrund:

Background: The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alternative splicing results in multiple transcript variants.

Gene Full Name: aconitase 1

Gen-ID: 48

UniProt: P21399

Pathways: Transition Metal Ion Homeostasis