HAAO Antikörper (AA 52-286)

Produktnummer ABIN7964899

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch HAAO in WB, ELISA, IF und ICC. Es zeigt Reaktivität gegenüber Proben von Human und Ratte.

Kurzübersicht für HAAO Antikörper (AA 52-286) (ABIN7964899)

Target: HAAO (3-hydroxyanthranilate 3,4-Dioxygenase (HAAO))

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HAAO Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Güteklasse: Carrier-free

Produktdetails anti-HAAO Antikörper

Bindungsspezifität: AA 52-286

Verwendungszweck: Anti-HAAO Antibody

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Homologie: Human HAAO shares 86.3%,88.5% amino acid (aa) sequence identity with mouse,rat HAAO,respectively.

Produktmerkmale: Anti-HAAO Antibody. Tested in ELISA, IF, ICC, WB applications. This antibody reacts with Human, Rat.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human HAAO recombinant protein (Position: E52-G286). Human HAAO shares 86.3% and 88.5% amino acid (aa) sequence identity with mouse and rat HAAO, respectively.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.25-0.5 μg/mL, Human, Rat Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human ELISA, 0.1-0.5 μg/mL, -

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu HAAO

Target: HAAO (3-hydroxyanthranilate 3,4-Dioxygenase (HAAO))

Andere Bezeichnung: HAAO

Hintergrund:

Background: 3-hydroxyanthranilate 3,4-dioxygenase (EC 1.13.11.6) is an enzyme encoded by the HAAO gene. 3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN.

Gene Full Name: 3-hydroxyanthranilate 3,4-dioxygenase

Molekulargewicht: 33 kDa

Gen-ID: 23498

UniProt: P46952