SMC3 Antikörper (acLys105, acLys106, C-Term)

Produktnummer ABIN7938499

Dieser Maus Monoklonal Antikörper detektiert spezifisch SMC3 in WB. Es zeigt Reaktivität gegenüber Proben von Human und Maus.

Kurzübersicht für SMC3 Antikörper (acLys105, acLys106, C-Term) (ABIN7938499)

Target: SMC3 (Structural Maintenance of Chromosomes 3 (SMC3))

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SMC3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-SMC3 Antikörper

Bindungsspezifität: acLys105, acLys106, C-Term

Verwendungszweck: SMC3 K105acK106ac antibody (mAb)

Aufreinigung: Protein G Chromatography

Immunogen: This SMC3 antibody was raised against a peptide in the C-terminal region of human SMC3.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: WB*: 1:500 - 1:1,000 dilution The addition of 0.05 % Tween 20 in the blocking buffer and primary antibody incubation buffer is recommended to aid in detection by Western blot. Individual optimization may be required.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Purified IgG in PBS, 30 % glycerol, 0.035 % Azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Lagerung: -20 °C

Informationen zur Lagerung: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Haltbarkeit: 24 months

Details zu SMC3

Target: SMC3 (Structural Maintenance of Chromosomes 3 (SMC3))

Andere Bezeichnung: SMC3

Hintergrund:

Background_Plain: The Structural Maintenance of Chromosomes (SMC) family proteins play critical roles in various nuclear events that require structural changes of chromosomes, including mitotic chromosome organization, DNA recombination and repair and global transcriptional repression.SMC3 is a component of the cohesin complex that plays an essential role during chromatid segregation. SMC3 is also involved in DNA recombination and repair, mitotic chromosome organization and microtubule-mediated intracellular transport. SMC3 is acetylated during replication, which is essential for cohesion, and is phosphorylated by ATM after DNA double strand breakage. This antibody is acetylated at lysine 105/106.SMC3 is frequently elevated in human colon carcinoma and overexpression of the protein transforms fibroblasts.

Aliases: BAM, BMH, HCAP, CDLS3, CSPG6, SMC3L1

Molekulargewicht: 141 kDa

NCBI Accession: NP_005436

Pathways: Stem Cell Maintenance