NAT10 Antikörper

Produktnummer ABIN7938364

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch NAT10 in WB. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für NAT10 Antikörper (ABIN7938364)

Target: NAT10 (N-Acetyltransferase 10 (GCN5-Related) (NAT10))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NAT10 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-NAT10 Antikörper

Verwendungszweck: NAT10 antibody (pAb)

Aufreinigung: Protein A Chromatography

Immunogen: This antibody was raised against a human RNA cytidine acetyltransferase isoform a.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1 - 4 μg dilution

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Purified IgG supplied in 62 mM Trisodium citrate, 87 mM Tris pH 7, 30 % glycerol, 0.035 % Sodium Azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Lagerung: -20 °C

Informationen zur Lagerung: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Haltbarkeit: 24 months

Details zu NAT10

Target: NAT10 (N-Acetyltransferase 10 (GCN5-Related) (NAT10))

Andere Bezeichnung: NAT10

Hintergrund:

Background_Plain: NAT10 (N-Acetyltransferase 10) antibody is a RNA cytidine acetyltransferase that catalyzes the formation of N(4)- acetylcytidine (ac4C) modification on mRNAs, 18S rRNA and tRNAs and mediates the formation of ac4C at position 1842 in 18S rRNA. NAT10 requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. In addition to RNA acetyltransferase activity, NAT10 is also able to acetylate lysine residues of proteins, such as histones, microtubules, p53/TP53 and MDM2, in vitro. It activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization. NAT10 involved in the regulation of centrosome duplication by acetylating CENATAC during mitosis, promoting SASS6 proteasome degradation.

Aliases: N-Acetyltransferase 10

Molekulargewicht: 130 kDa

NCBI Accession: NP_078938