METTL14 Antikörper

Produktnummer ABIN7938342

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch METTL14 in WB und IP. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für METTL14 Antikörper (ABIN7938342)

Target: METTL14 (Methyltransferase Like 14 (METTL14))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser METTL14 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP)

Produktdetails anti-METTL14 Antikörper

Verwendungszweck: METTL14 antibody (pAb)

Aufreinigung: Affinity Purified

Immunogen: This antibody was raised against a human peptide containing methyltransferase 14.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500 - 1:2000 dilution IP: 4 µL per IP

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Purified in PBS with 30 % glycerol and 0.035 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Lagerung: -20 °C

Informationen zur Lagerung: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Haltbarkeit: 24 months

Details zu METTL14

Target: METTL14 (Methyltransferase Like 14 (METTL14))

Andere Bezeichnung: METTL14

Hintergrund:

Background_Plain: N6-methylated adenine (m6A) is prevalently present in nearly all RNA types and can be found in all organisms from bacteria to humans. It preferentially appears around stop codons and within long internal exons in mammalian messager RNAs. m6A plays an important role in the efficiency of mRNA splicing, processing, translation efficiency, editing and mRNA stability. m6A also takes place in other RNA molecules, such as primary miRNA (pri-miRNAs). METTL14 (methyltransferase-like 14)forms a stable N6-methyltransferase heterodimer complex with METTL3, which catalyzes the generation of m6A modification on mammalian nuclear RNAs. METTL3 is the catalytically active subunit, while METTL14 plays a structural role critical for substrate recognition.

Aliases: Methyltransferase Like 14, EC 2.1.1.62, N6-methyltransferase

Molekulargewicht: 55kDa

NCBI Accession: NP_066012