Rekombinanter KAT5 Antikörper

Produktnummer ABIN7938310

Dieser Kaninchen Monoklonal Antikörper detektiert spezifisch KAT5 in IF. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für Rekombinanter KAT5 Antikörper (ABIN7938310)

Target: KAT5 (K(lysine) Acetyltransferase 5 (KAT5))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser KAT5 Antikörper ist unkonjugiert

Applikation: Immunofluorescence (IF)

Klon: 230181D5

Produktdetails anti-KAT5 Antikörper

Verwendungszweck: KAT5 antibody (rAb), 100 μg (Clone 230181D5)

Aufreinigung: Protein A Chromatography

Immunogen: This antibody was raised against the KAT5 fusion protein.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF: 1:200-1:800 dilution

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Purified IgG in PBS, pH 7.3, with 50 % glycerol and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Lagerung: -20 °C

Informationen zur Lagerung: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Haltbarkeit: 24 months

Details zu KAT5

Target: KAT5 (K(lysine) Acetyltransferase 5 (KAT5))

Andere Bezeichnung: KAT5

Hintergrund:

Background_Plain: KAT5 (K(Lysine) Acetyltransferase 5) is the atalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation.

Aliases: TIP, ESA1, PLIP, TIP60, cPLA2, HTATIP, ZC2HC5, HTATIP1

Molekulargewicht: 60 kDa

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway