ING5 Antikörper

Produktnummer ABIN7938284

Der Ratte Monoklonal anti-ING5 Antikörper wird verwendet zum Nachweis von ING5 in Proben von Human. Er wurde validiert für WB und IP.

Kurzübersicht für ING5 Antikörper (ABIN7938284)

Target: ING5 (Inhibitor of Growth Family, Member 5 (ING5))

Reaktivität: Human

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser ING5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP)

Klon: 7A11

Produktdetails anti-ING5 Antikörper

Verwendungszweck: ING5 antibody (mAb) (Clone 7A11)

Aufreinigung: Protein G Chromatography

Immunogen: This antibody was raised against full length recombinant human ING5 (Inhibitor of growth protein 5) protein.

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: WB: 0.5 - 2 μg/mL IP: 5 μg/mL This antibody is also available as an AbFlex engineered recombinant antibody. For details on the corresponding AbFlex Recombinant Antibody, see Catalog No. 91329.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Lagerung: -20 °C

Informationen zur Lagerung: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Haltbarkeit: 24 months

Details zu ING5

Target: ING5 (Inhibitor of Growth Family, Member 5 (ING5))

Andere Bezeichnung: ING5

Hintergrund:

Background_Plain: ING5 (Inhibitor of Growth 5) possesses different structural and functional elements, including a PHD (plant homeodomain), an NCR (novel conserved region), a LZL (leucine zipper like) finger, and two NLS (nuclear localization sequence) motifs. ING proteins bind to methylated core histones through their PHD motif, notably ING5 reads histone H3 when di- or trimethylated at lysine 4 (H3K4me2/3). ING5 is a subunit of two distinct histone acetyltransferase (HAT) complexes with HBO1 or MOZ/MORF as the two catalytic subunits. These complexes contain two different alternative scaffolding proteins, i.e. a BRPF protein or a JADE protein, that determine their specificity towards different core histones. ING complexes appear to participate in transcription, for example by interacting with transcriptional regulators such as the tumor suppressor p53 and through the ability of ING5 to recognize H3K4me3, a mark associated with open chromatin and transcribed genes.

Aliases: Inhibitor of growth protein 5, p28ING5

Molekulargewicht: 30 kDa

NCBI Accession: NP_001317091

Pathways: Chromatin Binding