Rekombinanter CBX5 Antikörper

Produktnummer ABIN7938268

Dieser Kaninchen Monoklonal Antikörper detektiert spezifisch CBX5 in WB. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für Rekombinanter CBX5 Antikörper (ABIN7938268)

Target: CBX5 (Chromobox Homolog 5 (CBX5))

Antikörpertyp: Recombinant Antibody

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser CBX5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: 240145F11

Produktdetails anti-CBX5 Antikörper

Verwendungszweck: HP1 antibody (rAb), 100 μg (Clone 240145F11)

Aufreinigung: Protein A Chromatography

Immunogen: This antibody was raised against the HP1 fusion protein.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:5000-1:50000 dilution

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Purified IgG in PBS, pH 7.3, with 50 % glycerol and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Lagerung: -20 °C

Informationen zur Lagerung: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Haltbarkeit: 24 months

Details zu CBX5

Target: CBX5 (Chromobox Homolog 5 (CBX5))

Andere Bezeichnung: HP1

Hintergrund:

Background_Plain: HP1 (Heterochromatin protein 1) is a chromosomal protein that participates in both chromatin packaging and gene silencing. Three HP1 isoforms (a, b and g) occur in mammals. The chromodomain (Chromatin Organization Modifier) of HP1a is responsible for binding to Histone H3 methyl Lys9, although additional factors are required to specify the HP1 targeting. The chromoshadow domain mediates interactions with a number of nuclear proteins, including SuvH39 (a Histone H3 Lysine methyltransferase), the DNA methyltransferases DNMT1 and DNMT3A or the large subunit of the chromatin assembly factor-1 (CAF-1). Dysfunction of HP1a plays a critical role in tumorigenesis, and is implicated in the invasive/metastatic phenotype of breast cancer.

Aliases: CBX5, HP1, Hp1a

Molekulargewicht: 22 kDa