GLYR1 Antikörper (C-Term)

Produktnummer ABIN7938142

Der Kaninchen Polyklonal anti-GLYR1 Antikörper (ABIN7938142) detektiert spezifisch GLYR1 in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für GLYR1 Antikörper (C-Term) (ABIN7938142)

Target: GLYR1 (Glyoxylate Reductase 1 Homolog (GLYR1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GLYR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-GLYR1 Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: GLYR1 antibody (pAb)

Aufreinigung: Affinity Purified

Immunogen: This antibody was raised against a peptide within the C-terminal region of human GLYR1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB*: 0.5 - 2 μg/mL *Note: Many chromatin-bound proteins are not soluble in a low salt nuclear extract and fractionate to the pellet. Therefore, we recommend a High Salt / Sonication Protocol when preparing nuclear extracts for Western blot.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Purified IgG in 70 mM Tris, 105 mM NaCl, 0.07 mM EDTA, 31 mM glycine, 30 % glycerol, and 0.035 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Lagerung: -20 °C

Informationen zur Lagerung: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Haltbarkeit: 24 months

Details zu GLYR1

Target: GLYR1 (Glyoxylate Reductase 1 Homolog (GLYR1))

Andere Bezeichnung: GLYR1

Hintergrund:

Background_Plain: GLYR1 / NDF (nucleosome-destabilizing factor) that is recruited to gene bodies during transcriptional activation and facilitates Pol II transcription through nucleosomes, where it is proposed to ""unzip"" chromatin during transcription, pushing the polymerase past pause points. It was discovered as a factor that allows p300 to acetylate Histone H3K56, which is normally an inaccessible residue for this modification. GLYR1 is shown to associate with a subset of highly transcribed genes tending to have longer mRNAs rather than shorter, and is also at a significant subset of loci containing the Histone H3K36me3. GLYR1 is expressed at high levels in most tissue types, including stem cells, and has been found to be overexpressed in breast cancer.

Aliases: Glyoxylate Reductase 1 Homolog, HIBDL, HNDF, NDF

Molekulargewicht: 65 kDa

NCBI Accession: NP_115958