TMEM38B Antikörper (Cytoplasmic Loop, Intracellular)

Produktnummer ABIN7885622

Der Kaninchen Polyklonal anti-TMEM38B Antikörper (ABIN7885622) detektiert spezifisch TMEM38B in WB, IHC und IC. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für TMEM38B Antikörper (Cytoplasmic Loop, Intracellular) (ABIN7885622)

Target: TMEM38B (Transmembrane Protein 38B (TMEM38B))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TMEM38B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunochromatography (IC)

Güteklasse: Carrier-free

Produktdetails anti-TMEM38B Antikörper

Bindungsspezifität: AA 116-126, Cytoplasmic Loop, Intracellular

Verwendungszweck: A Rabbit Polyclonal Antibody to TRIC-B Channel

Homologie: Mouse,human - identical

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)GMKEVTRTWKIVG, corresponding to amino acid residues 116-126 of rat TRIC-B

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: 1:200

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7237524)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 0.2 mL double distilled water (DDW)

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Konservierungsmittel: Without preservative

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu TMEM38B

Target: TMEM38B (Transmembrane Protein 38B (TMEM38B))

Andere Bezeichnung: Trimeric intracellular cation channel type B

Hintergrund:

Synonyms: Trimeric intracellular cation channel type B, Transmembrane protein 38B

Description: Intracellular Ca2+ levels are important in proper cellular functions and have prominent roles in various cell signaling pathways and are crucial for muscle contractions. Indeed, an important step leading to muscle contraction is the massive release of Ca2+ ions from the endoplasmic/sarcoplasmic reticulum (ER/SR) to the cytosol. A battery of results suggest that specific K+ channels are important to counteract the Ca2+ outflow in order to neutralize the negative potential created by the movement of Ca2+ ions. It is believed that TRIC channels are responsible for neutralizing this negative potential1,2.Trimeric intracellular cation-specific (TRIC) channels are critical for proper management of intracellular stores. TRIC-A and TRIC-B both belong to this family and are both permeable to monovalent ions with a preference for K+ 3. Both channels are localized to the ER/SR membrane. Each TRIC subunit contains three transmembrane domains, a cytoplasmic C-terminus and a luminal N-terminus. Functional entities are formed by homotrimerizarion4. The activity of TRIC-A is regulated by voltage whereas that of TRIC-B can be regulated by different mechanisms3.Knockout studies of these channels have shown that TRIC-A knockout mice are viable while those of TRIC-B die at the neonatal stage5.TRIC-A is mostly expressed in excitable tissues like the brain and muscle while TRIC-B is ubiquitously expressed.

Gen-ID: 362521

UniProt: Q68FV1