TMEM38A Antikörper (C-Term, Intracellular)

Produktnummer ABIN7885621

Der Kaninchen Polyklonal anti-TMEM38A Antikörper wird verwendet zum Nachweis von TMEM38A in Proben von Ratte und Maus. Er wurde validiert für WB, IHC und IC.

Kurzübersicht für TMEM38A Antikörper (C-Term, Intracellular) (ABIN7885621)

Target: TMEM38A (Transmembrane Protein 38A (TMEM38A))

Reaktivität: Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TMEM38A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunochromatography (IC)

Güteklasse: Carrier-free

Produktdetails anti-TMEM38A Antikörper

Bindungsspezifität: AA 259-274, C-Term, Intracellular

Verwendungszweck: A Rabbit Polyclonal Antibody to TRIC-A Channel

Homologie: Mouse - identical, human - will not recognize human TRIC-A

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)DNHGAPHGMGLGTQHS, corresponding to amino acid residues 259-274 of rat TRIC-A

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: 1:200

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7237521)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 0.2 mL double distilled water (DDW)

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Konservierungsmittel: Without preservative

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu TMEM38A

Target: TMEM38A (Transmembrane Protein 38A (TMEM38A))

Andere Bezeichnung: Trimeric intracellular cation channel type A

Hintergrund:

Synonyms: Trimeric intracellular cation channel type A, 27 kDa sarcoplasmic reticulum protein, Transmembrane protein 38A

Description: Intracellular Ca2+ levels are important in proper cellular functions and have prominent roles in various cell signaling pathways and are crucial for muscle contractions. Indeed, an important step leading to muscle contraction is the massive release of Ca2+ ions from the endoplasmic/sarcoplasmic reticulum (ER/SR) to the cytosol. A battery of results suggest that specific K+ channels are important to counteract the Ca2+ outflow in order to neutralize the negative potential created by the movement of Ca2+ ions. It is believed that TRIC channels are responsible for neutralizing this negative potential1,2.Trimeric intracellular cation-specific (TRIC) channels are critical for proper management of intracellular stores. TRIC-A and TRIC-B both belong to this family and are both permeable to monovalent ions with a preference for K+ 3. Both channels are localized to the ER/SR membrane. Each TRIC subunit contains three transmembrane domains, a cytoplasmic C-terminus and a luminal N-terminus. Functional entities are formed by homotrimerizarion4. The activity of TRIC-A is regulated by voltage whereas that of TRIC-B can be regulated by different mechanisms3.Knockout studies of these channels have shown that TRIC-A knockout mice are viable while those of TRIC-B die at the neonatal stage5.TRIC-A is mostly expressed in excitable tissues like the brain and muscle while TRIC-B is ubiquitously expressed.

Gen-ID: 306327

UniProt: A6ZIQ8