TMEM119 Antikörper (Extracellular, N-Term) (PE)

Produktnummer ABIN7885618

Der Kaninchen Polyklonal anti-TMEM119 Antikörper wird verwendet zum Nachweis von TMEM119 in Proben von Maus und Ratte. Er wurde validiert für FACS und LCI.

Kurzübersicht für TMEM119 Antikörper (Extracellular, N-Term) (PE) (ABIN7885618)

Target: TMEM119 (Transmembrane Protein 119 (TMEM119))

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TMEM119 Antikörper ist konjugiert mit PE

Applikation: Flow Cytometry (FACS), Live Cell Imaging (LCI)

Produktdetails anti-TMEM119 Antikörper (PE)

Bindungsspezifität: AA 53-67, Extracellular, N-Term

Verwendungszweck: A Rabbit Polyclonal Antibody to TMEM119 (extracellular) conjugated to R-Phycoerythrin (R-PE) fluorophore.

Homologie: Rat - 12 out of 15 amino acid residues identical. This antibody will not recognize human TMEM119

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)GTPAFSPTPERPQPT, corresponding to amino acid residues 53 - 67 of mouse TMEM119 

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7582046)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 50 μL double distilled water (DDW).

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu TMEM119

Target: TMEM119 (Transmembrane Protein 119 (TMEM119))

Andere Bezeichnung: Transmembrane Protein 119

Hintergrund:

Synonyms: Transmembrane Protein 119, Osteoblast induction factor, OBIF

Description:

Transmembrane protein 119, Tmem119, is a bone formation related factor that belongs to a group of bone morphogenetic proteins (BMPs). It is a class IA single pass transmembrane protein¹.

Tmem119 promotes the differentiation of myoblasts (embryonic precursors of muscle cells) into osteoblasts and plays a role in numerous BMP signaling pathways^1,2.

Tmem119 is uniquely expressed in microglia cells and it is therefore used as a < a href="https://www.alomone.com/c/microglia-proteins-research-areas">microglia-specific homeostatic marker that can assist in differentiating microglia cells from peripherally derived macrophages in the brain³. This marker is very important for diagnosing CNS disease: monocytes/macrophages are key cellular modulators of brain homeostasis. In the healthy brain resident microglia are the predominant macrophage cell population but when the blood-brain barrier is leaking peripheral monocytes/macrophages can infiltrate the brain and participate in CNS disease pathogenesis. Distinguishing these two monocytes/macrophages populations is often challenging and hence the existence of a highly expressed and robust microglia marker such as Tmem119 is very important⁴.

Gen-ID: 231633

UniProt: Q8R138