TMEM108 Antikörper (Extracellular Loop)

Produktnummer ABIN7885615

Der Kaninchen Polyklonal anti-TMEM108 Antikörper wird verwendet zum Nachweis von TMEM108 in Proben von Human, Maus und Ratte. Er wurde validiert für WB, FACS, IHC und LCI.

Kurzübersicht für TMEM108 Antikörper (Extracellular Loop) (ABIN7885615)

Target: TMEM108 (Transmembrane Protein 108 (TMEM108))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TMEM108 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (IHC), Live Cell Imaging (LCI)

Produktdetails anti-TMEM108 Antikörper

Bindungsspezifität: AA 208-223, Extracellular Loop

Verwendungszweck: A Rabbit Polyclonal Antibody to TMEM108 (Extracellular)

Homologie: Rat,mouse - 15 out of 16 amino acid residues identical.

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)GQKRPLGKIFQIYKGN, corresponding to amino acid residues 208 - 223 of human TMEM108

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The optimal concentration should be determined by the user

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Konzentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu TMEM108

Target: TMEM108 (Transmembrane Protein 108 (TMEM108))

Andere Bezeichnung: TMEM108

Hintergrund:

Synonyms: Transmembrane Protein 108, Retrolinkin, RTLN

Description:

TMEM108 (Transmembrane Protein 108) is a transmembrane protein originally identified as Retrolinkin, a protein involved in retrograde axon transport in the brain.1

TMEM108 is predominantly expressed in the brain where it has roles in neural connectivity and plasticity.

Indeed, TMEM108 has garnered attention in neuropsychiatric research due to its involvement in several cellular processes critical for proper brain function. A growing body of evidence links TMEM108 dysregulation to a range of neuropsychiatric disorders, including schizophrenia, bipolar disorder and major depressive disorder (MDD).2,3

TMEM108 plays a role in dendritic spine formation and synaptic transmission in neurons. Abnormalities in these processes can disrupt neural circuitry, which is a common feature in neuropsychiatric conditions. Disrupted synaptic connectivity has been implicated in the cognitive and behavioral symptoms observed in disorders such as schizophrenia.4,5

Beyond neurons, TMEM108 is expressed in oligodendrocytes and their precursors. Impaired oligodendrocyte function and myelin integrity can affect signal propagation along axons, potentially contributing to the white matter abnormalities frequently reported in psychiatric disorders. This dual role in both neuronal and glial cells positions TMEM108 as a key factor in maintaining overall brain network integrity.6

Given its multifaceted role in brain physiology, TMEM108 is being investigated as a potential biomarker for early diagnosis and prognosis in neuropsychiatric disorders. Understanding its function could also pave the way for developing targeted therapies aimed at restoring synaptic and myelin integrity.

Gen-ID: 66000

UniProt: Q6UXF1