SYN2 Antikörper (Domain G, Intracellular)

Produktnummer ABIN7885548

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch SYN2 in WB, IHC und IF. Es zeigt Reaktivität gegenüber Proben von Maus und Ratte.

Kurzübersicht für SYN2 Antikörper (Domain G, Intracellular) (ABIN7885548)

Target: SYN2 (Synapsin II (SYN2))

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SYN2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Güteklasse: Carrier-free

Produktdetails anti-SYN2 Antikörper

Bindungsspezifität: AA 438-450, Domain G, Intracellular

Verwendungszweck: A Rabbit Polyclonal Antibody to Synapsin II

Homologie: Mouse - identical, human- 12,13 amino acid residues identical

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)SGTLKEPDSSKTP, corresponding to amino acid residues 438-450 of rat Synapsin-2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:200

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7237311)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 0.2 mL double distilled water (DDW)

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Konservierungsmittel: Without preservative

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu SYN2

Target: SYN2 (Synapsin II (SYN2))

Andere Bezeichnung: Synapsin-2

Hintergrund:

Synonyms: Synapsin-2

Description: Synapsins are a family of ten homologous neuronal phosphoproteins evolutionarily conserved in invertebrate and vertebrate organisms. Synapsins appear to be crucial determinants for the fine-tuning of synaptic transmission and for synaptic remodeling. This is particularly evident in several paradigms of short-term plasticity (STP), which are specifically affected by mutations or malfunctioning of synapsin proteins. Notably, knockout of synapsin-2 in mice causes fully generalized forebrain seizures from the age of 2 months1.All synapsins, including synapsin-2, are composed of a highly homologous N-terminal region, and a more variable C-terminus. The N-terminal homologous region can be divided in three domains, namely domain A, B and C, which, except for domain B, are highly conserved across isoforms and species. Domain A is contains the phosphorylation site for PKA and CaMKI. Domain B, rich in small amino acids, is considered as a linker region connecting domain A to domain C. Domain C is a large region of about 300 amino acids, containing both hydrophobic and highly charged sequences with the potential to assume α-helix and β-sheet conformations. It shows extensive homology amongst the various members of the family, and mediates the core functions of synapsins1.

Gen-ID: 29179

UniProt: Q63537