SYNDIG1 Antikörper (Intracellular, N-Term)

Produktnummer ABIN7885546

Der Kaninchen Polyklonal anti-SYNDIG1 Antikörper wird verwendet zum Nachweis von SYNDIG1 in Proben von Maus, Ratte und Human. Er wurde validiert für WB.

Kurzübersicht für SYNDIG1 Antikörper (Intracellular, N-Term) (ABIN7885546)

Target: SYNDIG1 (Synapse Differentiation Inducing 1 (SYNDIG1))

Reaktivität: Maus, Ratte, Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SYNDIG1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Güteklasse: Carrier-free

Produktdetails anti-SYNDIG1 Antikörper

Bindungsspezifität: AA 119-132, Intracellular, N-Term

Verwendungszweck: A Rabbit Polyclonal Antibody to SynDIG1

Homologie: Mouse,human - identical

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)RSPTKDSLEYPDGK, corresponding to amino acid residues 119-132 of rat SynDIG1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200-1:400

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7237303)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 0.2 mL double distilled water (DDW)

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Konservierungsmittel: Without preservative

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu SYNDIG1

Target: SYNDIG1 (Synapse Differentiation Inducing 1 (SYNDIG1))

Andere Bezeichnung: Synapse differentiation-inducing gene protein 1

Hintergrund:

Synonyms: Synapse differentiation-inducing gene protein 1, Transmembrane Protein 90B, TMEM90B, Dispanin subfamily C member 2, DSPC2

Description: SynDIG1 (Synapse differentiation induced gene 1) is a brain-specific, highly conserved type II integral membrane protein detected at excitatory synapses. The protein is responsible for the regulation of excitatory synapse number and strength in hippocampal neurons. The protein plays an important role during synapse development in regulating AMPA receptor (AMPAR) and PSD-95 content at excitatory synapses1,2.SynDIG family includes four members: SynDIG1-4. SynDIG1 structure includes a large intracellular N-terminal region followed by a single transmembrane domain and a second hydrophobic segment that does not span the membrane. The membrane-associated region forms a three-helical bundle with two cysteine residues located at positions 191 and 192 in the juxta-transmembrane region exposed to the cytoplasm1,2.In studies conducted on mice, deletion of endogenous SynDIG1 in the mouse brain results in a significant decrease in excitatory synapse maturation, but not in synapse composition. Thus, SynDIG1 is not required for synaptogenesis in vivo1. Contrarily, overexpression of SynDIG1 in cultures of dissociated rat hippocampal neurons shows a significant increase in excitatory synapse strength and number.

Gen-ID: 362235

UniProt: Q58DZ9

Pathways: Synaptic Membrane