SUCNR1 Antikörper (3rd Extracellular Loop)

Produktnummer ABIN7885545

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch SUCNR1 in WB, IHC, FACS und LCI. Es zeigt Reaktivität gegenüber Proben von Human, Ratte und Maus.

Kurzübersicht für SUCNR1 Antikörper (3rd Extracellular Loop) (ABIN7885545)

Target: SUCNR1 (Succinate Receptor 1 (SUCNR1))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SUCNR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Live Cell Imaging (LCI)

Güteklasse: Carrier-free

Produktdetails anti-SUCNR1 Antikörper

Bindungsspezifität: 3rd Extracellular Loop, AA 248-262

Verwendungszweck: A Rabbit Polyclonal Antibody to Succinate Receptor 1

Homologie: 15 amino acid residues identical,Mouse - 14, human - 12

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)RNVRIASRLDSWPQG, corresponding to amino acid residues 248-262 of rat GPR91/Succinate Receptor 1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200

FC: 2.5 mg per reaction

ICC: The optimal concentration should be determined by the user

IHC: 1:200

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7237300)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 0.2 mL double distilled water (DDW)

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Konservierungsmittel: Without preservative

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu SUCNR1

Target: SUCNR1 (Succinate Receptor 1 (SUCNR1))

Andere Bezeichnung: G-protein coupled receptor 91

Hintergrund:

Synonyms: G-protein coupled receptor 91, Succinate receptor 1

Description: GPR91 (Succinate Receptor 1), a member of the GPCR superfamily, is specifically activated by extracellular succinate outside the tricarboxylic acid cycle, resulting in activation of paracrine and endocrine effectors. Activation of GPR91 is associated with several diseases, including hypertension and diabetes1,2.GPR91 was shown to regulate normal retinal vascularization, proliferative ischemic retinopathy and cortical revascularization post-ischemia. Activation of GPR91 influences different tissues such as kidney, heart, retina, white adipose tissue, and liver.Through the activation of GPR91, succinate affects motility, migration, and growth of dendritic cells. In addition, the receptor directly promotes chemotaxis and potentiates activation initiated by Toll-like receptor agonists in dendritic cells1-3.In the heart GPR91 mediates succinate-induced cardiomyocyte death. It was demonstrated that upholding levels of serum succinate can cause cardiac hypertrophy through the activation of the GPR911,2.

Gen-ID: 408199

UniProt: Q6IYF9