S1PR2 Antikörper (2nd Cytoplasmic Loop)

Produktnummer ABIN7885537

Der Kaninchen Polyklonal anti-S1PR2 Antikörper wird verwendet zum Nachweis von S1PR2 in Proben von Human, Maus und Ratte. Er wurde validiert für WB und IHC.

Kurzübersicht für S1PR2 Antikörper (2nd Cytoplasmic Loop) (ABIN7885537)

Target: S1PR2 (Sphingosine-1-Phosphate Receptor 2 (S1PR2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser S1PR2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Güteklasse: Carrier-free

Produktdetails anti-S1PR2 Antikörper

Bindungsspezifität: 2nd Cytoplasmic Loop, AA 129-146

Verwendungszweck: A Rabbit Polyclonal Antibody to Sphingosine 1-Phosphate Receptor 2

Homologie: Rat - 17,18 amino acid residues identical, human - 16

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: ERQVALAKVKLYGSDKSC, corresponding to amino acid residues 129-146 of mouse S1PR2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:100

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7237271)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 0.2 mL double distilled water (DDW)

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Konservierungsmittel: Without preservative

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu S1PR2

Target: S1PR2 (Sphingosine-1-Phosphate Receptor 2 (S1PR2))

Andere Bezeichnung: Sphingosine 1-phosphate receptor 2

Hintergrund:

Synonyms: Sphingosine 1-phosphate receptor 2, S1P2, Endothelial differentiation G-protein coupled receptor 5, Lysophospholipid receptor B2, LPB2

Description: Lysophospholipids constitute a group of important lipid mediators, lysophosphatidic acid (LPA) a glycerolysophospholipid and sphingosine 1-phosphate (S1P), a lysosphingolipid. Sphingosine 1-phosphate is a bioactive lipid derived from metabolism of sphingomyelin1. Sphingosine 1-phosphate is implicated in the regulation of many cellular functions including proliferation, apoptosis, survival, adhesion, differentiation, and migration2.Sphingosine 1-phosphate exerts its activity through five distinct G-protein-coupled receptors, (also named endothelial differentiation gene receptors - EDG), S1PR1 (EDG-1), S1PR2 (EDG-5), S1PR3 (EDG-3), S1PR4 (EDG-6), and S1PR5 (EDG-8)3.Sphingosine 1-phosphate receptor 2 (S1PR2) is ubiquitously expressed. S1PR2 mRNA was detected in the brain, heart, spleen, liver, lung, thymus, kidney and skeletal muscle4. Unlike S1PR1, knockout of SIPR2 gene is not lethal5.

Gen-ID: 14739

UniProt: P52592

Pathways: Synaptic Membrane