SSTR2 Antikörper (C-Term, Intracellular)

Produktnummer ABIN7885528

Der Kaninchen Polyklonal anti-SSTR2 Antikörper wird verwendet zum Nachweis von SSTR2 in Proben von Human, Ratte und Maus. Er wurde validiert für WB und IHC.

Kurzübersicht für SSTR2 Antikörper (C-Term, Intracellular) (ABIN7885528)

Target: SSTR2 (Somatostatin Receptor 2 (SSTR2))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SSTR2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Güteklasse: Carrier-free

Produktdetails anti-SSTR2 Antikörper

Bindungsspezifität: AA 339-359, C-Term, Intracellular

Verwendungszweck: A Rabbit Polyclonal Antibody to Somatostatin Receptor Type 2

Homologie: Mouse,human - identical

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)ERSDSKQDKSRLNETTETQRT corresponding to residues 339-359 of rat SSTR2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:400

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7237235)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 0.2 mL double distilled water (DDW)

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Konservierungsmittel: Without preservative

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu SSTR2

Target: SSTR2 (Somatostatin Receptor 2 (SSTR2))

Andere Bezeichnung: SSTR2a

Hintergrund:

Synonyms: SSTR2a, SS2R, Smstr2, SRIF1A

Description: Somatostatin is a small cyclic peptide that is widely expressed throughout the central nervous system and peripheral tissues1. In peripheral tissues, somatostatin exerts inhibitory effects on secretion processes, whereas in the brain, it acts as a neurotransmitter in both a stimulatory and an inhibitory manner1,2.Somatostatin mediates its action via six high affinity G-protein coupled receptors (SSTR1, SSTR2a, SSTR2b, SSTR3, SSTR4, and SSTR5), which are encoded by five genes1,2. Expression of the different receptors is developmentally regulated in a time- and tissue-specific manner2.Somatostatin receptors have been found on a variety of neuroendocrine tumors, such as paragangliomas, carcinoids, and breast tumors3. Synthetic peptide derivatives of somatostatin have been successfully used in the treatment of neuroendocrine malignancies and in vivo imaging of tumors that are positive for somatostatin receptors4.In general, SSTR2 is the most common SSTR subtype found in human tumors, followed by SSTR1, with SSTR3 and SSTR4 being less common.

Gen-ID: 54305

UniProt: P30680