Sodium Channel-Pan (AA 1501-1518), (Intracellular Loop) Antikörper

Produktnummer ABIN7885404

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch Sodium Channel-Pan in IF, IHC, WB, IC und IP. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für Sodium Channel-Pan (AA 1501-1518), (Intracellular Loop) Antikörper (ABIN7885404)

Target: Sodium Channel-Pan

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB), Immunochromatography (IC), Immunoprecipitation (IP)

Güteklasse: Carrier-free

Produktdetails

Bindungsspezifität: AA 1501-1518, Intracellular Loop

Verwendungszweck: A Rabbit Polyclonal Antibody to Pan NaV Channel

Homologie: The epitope is identical in all isoforms of NaV1 in all vertebrates,and highly homologous in molluscan,insect voltage-gated Na+ channels

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: TEEQKKYYNAMKKLGSKK(C), corresponding to amino acid residues 1501-1518 of rat NaV1.1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 0.2 mL double distilled water (DDW)

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Konservierungsmittel: Without preservative

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Antigendetails

Target: Sodium Channel-Pan

Andere Bezeichnung: Pan sodium channel

Hintergrund:

Synonyms: Pan sodium channel, SP19

Description: Voltage-gated sodium channels (NaV) are essential for the generation of action potentials and for cell excitability.1 NaV channels are activated in response to depolarization and selectively allow flow of Na+ ions. To date, nine NaV α subunits have been cloned and named NaV1.1-NaV1.9.4-5 The NaV channels are classified into two groups according to their sensitivity to tetrodotoxin (TTX): TTX-sensitive (NaV1.1, NaV1.2, NaV1.3, NaV1.4, NaV1.6 and NaV1.7) and TTX-resistant (NaV1.5, NaV1.8 and NaV1.9).2-3Mammalian sodium channels are heterotrimers, composed of a central, pore-forming α subunit and two auxiliary β subunits. The expression of the α subunit isoform is developmentally regulated and tissue specific. Sodium channels in the adult central nervous system and heart contain β1 through β4 subunits, whereas sodium channels in adult skeletal muscle have only the β1 subunit.6,7

Gen-ID: 81574

UniProt: P04774