Regulating Synaptic Membrane Exocytosis 1 (RIMS1) (AA 1039-1054), (Intracellular) Antikörper

Produktnummer ABIN7885365

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch Regulating Synaptic Membrane Exocytosis 1 in WB. Es zeigt Reaktivität gegenüber Proben von Ratte und Maus.

Kurzübersicht für Regulating Synaptic Membrane Exocytosis 1 (RIMS1) (AA 1039-1054), (Intracellular) Antikörper (ABIN7885365)

Target: Regulating Synaptic Membrane Exocytosis 1 (RIMS1)

Reaktivität: Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: Western Blotting (WB)

Güteklasse: Carrier-free

Produktdetails

Bindungsspezifität: AA 1039-1054, Intracellular

Verwendungszweck: A Rabbit Polyclonal Antibody to RIM1

Homologie: human - 14,16 amino acid residues identical,Mouse - 15

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)RAKRGRSAESLHMTSE, corresponding to amino acid residues 1039-1054 of rat RIM1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7236714)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 0.2 mL double distilled water (DDW)

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Konservierungsmittel: Without preservative

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Antigendetails

Target: Regulating Synaptic Membrane Exocytosis 1 (RIMS1)

Andere Bezeichnung: Regulating synaptic membrane exocytosis 1

Hintergrund:

Synonyms: Regulating synaptic membrane exocytosis 1, Rab-3-interacting molecule 1, RIMS1

Description: RIM1 is a member of the RIM superfamily of proteins (Rim1-4). These genes express seven known RIM isoforms: RIM1α, 1β, RIM2α, 2β, 2γ, and RIM3γ and RIM4γ which serve as scaffolding proteins in presynaptic nerve terminals by interacting with several other protein components localized at the active zone, including Munc13, ELKS (or CAST), liprins and voltage-gated Ca2+ channels (VGCCs). RIM1 directly binds to the C-terminal regions of the α1 subunit of N- and P/Q-type calcium channels, and can also interact with the β auxiliary subunit of P/Q-type calcium channels1-3.RIM proteins were found to be required for normal Ca2+ triggering of exocytosis. This interaction with Ca2+ channel significantly slows channel inactivation resulting in increased Ca2+ influx during action potentials.Deficiency of RIM1 decreases presynaptic Ca2+ channel density. RIM proteins are involved in neurotransmitter release and contribute to long- and short-term synaptic plasticity.

Gen-ID: 84556

UniProt: Q9JIR4

Pathways: Synaptic Membrane, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport, Regulation of long-term Neuronal Synaptic Plasticity