PLXNB1 Antikörper (Extracellular, N-Term)

Produktnummer ABIN7885237

Der Kaninchen Polyklonal anti-PLXNB1 Antikörper wird verwendet zum Nachweis von PLXNB1 in Proben von Human, Maus und Ratte. Er wurde validiert für WB, IHC und FACS.

Kurzübersicht für PLXNB1 Antikörper (Extracellular, N-Term) (ABIN7885237)

Target: PLXNB1 (Plexin B1 (PLXNB1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PLXNB1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)

Güteklasse: Carrier-free

Produktdetails anti-PLXNB1 Antikörper

Bindungsspezifität: AA 1159-1174, Extracellular, N-Term

Verwendungszweck: A Rabbit Polyclonal Antibody to Plexin-B1 (extracellular)

Homologie: Human - identical. Rat - 13 out of 16 amino acid residues identical.

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)DPKVHSIFPARGPRAG, corresponding to amino acid residues 1159 - 1174 of mouse Plexin-B1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: The optimal concentration should be determined by the user

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 0.2 mL double distilled water (DDW)

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4

Konservierungsmittel: Without preservative

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu PLXNB1

Target: PLXNB1 (Plexin B1 (PLXNB1))

Andere Bezeichnung: PLXNB1

Hintergrund:

Synonyms: Semaphorin receptor SEP, PLXNB1

Description:

Plexin-B1 is a transmembrane receptor that belongs to the plexin family, a group of proteins best known for their role in semaphorin signaling. As a receptor for Class IV semaphorins, particularly Semaphorin 4D (Sema4D) and Semaphorin 4A (Sema4A), Plexin-B1 regulates diverse biological functions including cytoskeletal remodeling, cell adhesion, and migration. Given this broad range of interactions, Plexin-B1 has become recognized as a critical regulator in neural development, immune response, and cancer biology.1

In the central nervous system, Plexin-B1 plays a pivotal role in axonal guidance and synapse formation. The receptor-ligand interactions with both Sema4D and Sema4A deliver directional signals that influence neural wiring. Notably, these ligands can provide either attractive or repulsive cues, depending on cellular context.1

Beyond its developmental functions, Plexin-B1 contributes to neuroinflammatory processes. In experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis, the Sema4D-Plexin-B1 interaction promotes microglial activation and the release of nitric oxide, exacerbating neuronal damage.2

Plexin-B1 is also widely expressed in the immune system, where it contributes to immune cell communication and migration. Both Sema4D and Sema4A are important ligands in this context. Sema4A, like Sema4D, is expressed on activated T cells and antigen-presenting cells. When it binds to Plexin-B1, it modulates T-cell activation and can influence cytokine production and immune tolerance. This dual-ligand functionality expands the scope of Plexin-B1's involvement in both innate and adaptive immune responses. Together, these interactions underscore Plexin-B1's central role in orchestrating immune dynamics and maintaining immune homeostasis.3,4

Aberrant Plexin-B1 expression and signaling are frequently observed in cancer, where they contribute to tumor progression and metastasis. Overexpression of Plexin-B1 has been documented in several cancers, including prostate, pancreatic, and skin carcinomas, often correlating with increased invasiveness and poor prognosis.5,6

Gen-ID: 235611

UniProt: Q8CJH3